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Inflamm Bowel Dis 2011;17:22752286.ArticlePubMed 106

Abstract The balance of programmed cell death (PCD) mechanisms, including apoptosis, autophagy, necroptosis and others, is pivotal in cancer progression and treatment

The rise of alpha arbutin reflects this shift

Moreover, the relevance of one carbon metabolism is also highlighted by the association between the levels of folate in peripheral blood, DNA methylation and colorectal tumor staging (61)