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Due to hyperinflation and long-term unfavourable mechanical position, the diaphragm is forced to remain in a state of contraction, which is easy to cause the decline of diaphragm compliance and contraction force, leading to diaphragm fatigue (McKenzie et al., 2009) (Figure 1)

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When routinely worn, wearables can deliver useful information about motor activities, which are strongly influenced by fatigue (e.g., gait, balance, social contacts, sports, etc.)

Across COURAGE, ISCHEMIA, FAME 2, and MASS II, routine revascularization in stable disease does not reduce all-cause mortality relative to optimal medical therapy, though it improves angina and reduces urgent revascularization

This paper presents the first study of nusinersen in pre-symptomatic infants with SMA-I and SMA-II who were identified through family studies or newborn screening