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The analysis was performed on a SHIMADZU-LC30 ultrahigh-performance liquid chromatography (UHPLC) system coupled with an ACQUITY UPLC HSS T3 column (2.1 100 mm, 1.8 m) (Waters, Milford, MA, USA)

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This interesting finding shows that PAP is a potent toxic agent but also its biotransformation leads to formation of additional, toxic, conjugated products capable of damaging the kidney cells