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The chemical nature of the resin, coupled with its large adsorbent surface area relative to its volume (approximately 700 m2/g resin), gives it a high capacity to adsorb various uremic toxins in the medium- to high-molecular-weight range of molecules, including 2-m, homocysteine, parathyroid hormone, FGF23 and various cytokines, such as IL-6, TNF-alpha and TGF-alpha.20,36,4144,5153 Small molecules such as creatinine and uric acid are also retained in the cartridge, while urea, phosphorus and potassium are reinfused unchanged in the regenerated ultrafiltrate and subsequently dialyzed in the diffusive filter

This is due to the role of glycerol, which serves as the solvent as well as a carbonization promoter and surface passivation agent

Anirban Basu, National Brain Research Center (NBRC), India

Creutzfeldt)

doi: 10.3389/fmars.2026.1748819 Received 18 November 2025 Revised 16 March 2026 Accepted 18 March 2026 Published 13 April 2026 Volume 13 - 2026 Edited by Donald Behringer, University of Florida, United States Reviewed by Khor Waiho, University of Malaysia Terengganu, Malaysia Eric James Schott, University of Maryland, College Park, United States Updates Copyright 2026 Anastasiou, Christaki, Feidantsis, Georgoulis, Papadopoulos, Alvanou, Apostolidis, Mourtzinos, Giannakourou and Giantsis

Store in a cool dry place Colors may darken, which does not alter potency