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In the absence of SIRT4, a failure to undergo cell cycle arrest induced by DNA damage causes a delay in DNA repair and increased chromosomal instability, suggesting a tumor suppressor effect of SIRT4 151

Flow cytometric monitoring of constitutive MAPK phosphorylation and of pharmacodynamic MEK/MAPK inhibition in primary AML samples

10.1172/JCI21625 21

93,94 In T2D, AMPK activity is decreased from several ways

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