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Although no direct ligand has been identified for HER2/neu, it can be activated through overexpression or transactivation by ligands of other EGF family receptors (60, 61) In addition, the phosphatase protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase signalling by dephosphorylating key kinases involved in breast tumourigenesis, including HER1/EGFR, proto-oncogene tyrosine-protein kinase (Src), janus kinase (JAK), and signal transducer and activator of transcription (STAT)

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The outer MSN layer provides immobilization sites for chemically conjugating MGF, a variant subtype of IGF-1, via EDC/NHS chemistry

PMID 22146081

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