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The role of SENP2 was confirmed in vivo using adipocyte-specific Senp2 knockout ( Senp2 -aKO) mice

These results establish the importance of B cells and adaptive immunity in insulin resistance and suggest new diagnostic and therapeutic modalities for managing the disease. Anti-NMDA receptor encephalitis and late onset autism are recently recognised and related autoimmune disorders involving antibodies to NMDA (glutamatergic) receptors with prodromal symptoms reminiscent of a viral infection and that result in a wide range of movement and neuropsychiatric symptoms and neuroinflammation

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Extrinsic apoptosis is initiated through the activation of caspase-8, while intrinsic apoptosis is mediated by the mitochondrial release of cytochrome c and SMAC/DIABLO, leading to the activation of caspase-9, which in turn activates downstream effector caspases such as caspase-3 and caspase-7 [112, 114]

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