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The variation in the erythrocyte GSH system without nuclear capacity to restore homeostasis may be an early biomarker of chronic oxidative stress that could be a first step in the development of cardiometabolic complications

Amyotrophic Lateral Sclerosis ALS is a motor neuron disease, a progressive and ultimately fatal neurodegenerative disorder characterized by motor neuron degeneration and subsequent muscle atrophy

An example is fexofenadine (Allegra), an antihistamine used to relieve allergy symptoms that is available by prescription and over the counter

On the other hand, mechanistic experiments demonstrated that compound 67 promoted (i) an alteration in the energetic metabolism with a significant loss of ATP that is associated with the depolarization of mitochondrial potential ( m ), (ii) a decrease of intracellular ATP levels with an alteration of plasma membrane permeability, and (iii) a significant ROS production, which is the typical mode of action found for 4-aminoquinolines