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Using distinct HIF-1 antibodies for staining macrophages, dual-positive immunofluorescence for HIF-1 + and CD206 + macrophages was detected in proximity to capillaries (186), indicating that vascular neogenesis in jDM patients is regulated by the VEGF/HIF pathway, inducing HIF-1 and promoting CD206 expression in macrophages, which may lead to hypoxic damage to capillaries in DM patients

Thus, we identified GSTM2 as an important negative regulator in hepatic steatosis progress

Zhou J, Chuang Y, Redding-Ochoa J, Zhang R, Platero AJ, Barrett AH, et al

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doi: 10.3389/fphar.2022.872988 199 ZhangL