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Supplementary Materials The following supporting information can be downloaded at: Figure S1: Study Flow Diagram

These observations showed that Raman spectroscopy can be used for the analysis of conformational changes induced in IDPs by environmental cues, as well as for the identification of the conformational constituents of IDPs in their conformational ensembles (Maiti et al., 2004)

These are individualized cases, but ideal candidates are those open to trying a novel therapy in addition to conventional ones to achieve the best outcome

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Longer duration of therapy provided to poorly controlled subjects could result in larger changes in Hb A 1c as well as more substantial changes in neuropathic symptoms and objective assessment of small nerve fiber density and function

Although NNMT may affect nicotinamide levels and NAD+ pathways, the real impact in the body is still unclear