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Zhai et al., 2013)

doi:10.1056/NEJMp2003762 7

Their potential implications for cancer prevention and their role in regulating key epigenetic genes have been described in numerous investigations

The third pathway also involves the addition of a highly water-soluble molecule (glutathione)

Annovazzi, L., Mellai, M., Caldera, V., Valente, G

When deciding which solubility tag to use, it will be worth thinking carefully about the characteristics of the protein you are purifying, and which downstream applications you have in mind