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A protocol that produces no meaningful response over the cycle should be discontinued, not extended on the assumption that more time will produce results that have not appeared

Within each active month, the 5-days-on, 2-days-off schedule follows the same logic at the weekly level: it prevents tachyphylaxis (diminished response from constant exposure) while maintaining enough stimulus frequency to produce measurable visceral fat reduction

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Recent studies have shown that increased enzymatic activity of CD38 is linked to heart disease and neurological disorders [6, 7]