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One study found that after injecting high doses of vitamin B12 (specifically cyanocobalamin) into rodents, the B12 stayed in the bloodstream for a relatively short period, with a half-life ranging from 20 to 50 minutes

Blood pressure changes were not observed in clinical trials

Preclinical evidence shows AOD-9604 can stimulate chondrocyte differentiation and increase proteoglycan synthesis, which are both important steps in cartilage formation

Thus, elevated blood levels of homocysteine and MMA may both be indicators of vitamin B 12 deficiency

They do not imply therapeutic, diagnostic, or clinical benefit

Requires indefinite use