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Mitochondria, known for their role in cellular metabolism, are implicated in this process, as ROS are primarily derived from intracellular redox reactions, with mitochondria playing a significant role

10.1039/D4TB02834A 26 FasogbonI

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In addition, the oxidation of eIF2, observed in MCI IPL, might lead to its impaired activity leading to UPR defects and exacerbating the accumulation of unfolded/misfolded proteins (26) (FIGURE 2)

Identification of lactate dehydrogenase as a mammalian pyrroloquinoline quinone (PQQ)-binding protein

The rate of telomere attrition was shown to vary throughout a human lifetime (Turner et al., 2019)