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Also, increased MMP levels are accompanied by reduced TIMPs in aged skin, leading to an imbalance in the MMPs/TIMPs ratio and progressive collagen fragmentation [611]

PMID: 34552216 Acta Biomater2021 Apr 15:125:253-266

2024;8:e0559

526 : 108112 Arienti G, Ramacci MT, Maccari F, Casu A, Corazzi L

8 About half of the reported patients presented early (3 months to 2.5 years) with metabolic decompensation characterized by episodes of hypoketotic hypoglycemia, hyperammonemia, hepatomegaly, elevated transaminases, and hepatic encephalopathy