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By regulating neurotransmitter systems like dopamine, serotonin and acetylcholine, hesperidin can enhance synaptic transmission, improve neuronal communication, and protect against neurotransmitter imbalances associated with neurodegenerative disorders

Genetic polymorphisms in Keap1 or Nrf2 further influence individual susceptibility to HTN and response to therapy, highlighting the need for personalized approaches ( 6 Oxidative stress and diabetes mellitus OS in DM operates as both a causal driver and consequential amplifier of disease progression, accelerating metabolic dysfunction and tissue damage in a similar way as in HTN (Kaneto et al., 2022)

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Lennicke C., Cocheme H.M

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[3] In various cellular processes, NAD+-dependent/-consuming enzymes modify proteins post-translationally using NAD+ and its other forms as substrates