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NAD depletion may also underlie many age-related diseases such as cancer and neurodegenerative diseases like Alzheimers

J Allergy Clin Immunol 108(4):639646

Cells use NAD+ to get energy from fuel sources like glucose, amino acids, and fatty acids

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Additionally, as noted above we also found the up-regulation of Hsp70, a specific chaperone that forms complexes with other co-chaperones in maintaining hemostasis and is associated with intracellular organization of signaling systems and platelet function 24 , and expression of Hsp70 is an endogenous mechanism by which living cells adapt to stress 25