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This result is notable when compared to other medications in the same timeframe: - Cagrilintide (Novo Nordisk): 5.0% weight loss - Semaglutide (Novo Nordisk): 5.3% weight loss - Tirzepatide (Eli Lilly): 8.2% weight loss Despite the smaller sample size (N=12) and the early phase of clinical development, Petrelintide shows significant potential

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In-vivo vaccination effect The binding of antibodies to exogenous antigens (e.g., viral proteins) or tumor-associated antigens can promote their uptake, processing, and cross-presentation by antigen-presenting cells (e.g., DCs), ultimately leading to priming of CD8 + T cell effectors and induction of memory responses [38, 39]

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J Biol Chem 282:1842736 Pineda-Molina E, Klatt P, Vazquez J, Marina A, Garcia DL (2001) Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding