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To replenish intracellular GSH, cells synthesize GSH in a two-step metabolic pathway centred on the rate-limiting enzyme glutamate cysteine ligase (GCL), which is composed of a catalytic (GCLC) and a regulatory or modifier (GCLM) subunit, and the GSH synthetase (GS) 22

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Beridze, M

Proinflammatory cytokines predict the incidence of diabetic peripheral neuropathy over 5 years in Chinese type 2 diabetes patients: a prospective cohort study

3A illustrates a core subset of these differentially expressed genes (DEGs) based on stringent overlap criteria, only a small group of genes ( n = 25) overlapped concordantly (i.e., up- or downregulated in both strains), highlighting the distinct regulatory adjustments driven by glutathione depletion