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reported that TGF- suppresses complex III in human lung fibroblasts, leading to sustained ROS generation and profibrotic gene induction

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There are some studies investigating the safety and toxicity of SI, which indicate that consumption of raw saponin seeds may cause toxicity in humans due to the presence of phytotoxins (alkaloids, lectins, and saponins)

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Since the timing of ASP reporting and publishing has a two-quarter lag (for example, payment limits calculated using data reported from the first quarter of sales become effective two quarters later), we proposed that most recently published for purposes of this policy means the most recently updated NADAC survey available 30 days after the close of the quarter for which ASP data would have been reported if it were available