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While little is known on the sex differences in MTHFR polymorphisms, sex hormones, such as estrogen is known to play a protective effect in female patients with schizophrenia as for the impact of neurodevelopment and social maturation 55

The association between plasma levels of trimethylamine N-oxide and the risk of coronary heart disease in Chinese patients with or without type 2 diabetes mellitus

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It serves as a protective mechanism to regulate the passage of substances across the BBB and prevents physiologically irrelevant molecules in the peripheral circulation from entering the brain

In DR, downregulation of Kir4.1 reduces the ability of Mller cells to clear glutamate

Rhoads JP, Major AS