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336 The age-dependent decline of NAD + might be due to either enhanced consumption or reduced biosynthesis

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Finally, if the serum cobalamin concentration at the time of reevaluation is subnormal, further work-up is required to definitively diagnose the underlying disease process and cobalamin supplementation should be continued weekly or bi-weekly (for parenteral supplementation) or daily (for oral supplementation)

Concomitant corticosteroids as a third immunosuppressive therapy when used to induce remission, may further increase the relative risk of serious and opportunistic infections

Furthermore, because of its role in red blood cell production, it is crucial for the delivery of oxygen to tissues