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however, only a subset of the reviewed studies accounted for this factor

The industry doesn't talk about this because there's no financial incentive to do so

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AHAs and BHAs: Alpha hydroxy acids like glycolic acid and beta hydroxy acids like salicylic acid create low-pH environments that can destabilize copper peptide structures

CGRP, the most potent vasodilatory peptide identified to date, is widely distributed in the trigeminal ganglion and perivascular nerve fibers of cerebral blood vessels (3537)

We recommend getting labs done often to ensure levels are not too high