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Also, when blood-brain barrier (BBB) is disrupted by stroke and other brain diseases, it helps to transfer the systemic iron pool into neurons in the brain parenchyma, exacerbating ferroptosis (Datta et al., 2020

We also confirmed the beneficial effect of short-term treatment with NOx of apple embryos isolated from aged seeds, which stimulated total antioxidant activity in the embryonic axes (Ciacka et al

Auranofin Auranofin is an antiarthritic gold phosphine compound that also exhibits anticancer effects similar to those of cisplatin

110 Mechanistic studies have shown that combination therapy induces increased ROS and lipid peroxides and depletion of GSH, and downregulates ferroptosis inhibitory proteins, including FTH1, SLC7A11, GPX4, and FPN, 110 suggesting that -elemene is a novel inducer of ferroptosis

This is most obviously apparent for the large GST family