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Prior to the initiation of Depakote ER therapy, evaluation for UCD should be considered in the following patients: 1) those with a history of unexplained encephalopathy or coma, encephalopathy associated with a protein load, pregnancy-related or postpartum encephalopathy, unexplained mental retardation, or history of elevated plasma ammonia or glutamine

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2017a), or through heme importer, such as feline leukaemia virus subgroup C receptor2 (FLVCR2), heme responsive gene-1 (HRG1) and heme carrier protein 1 (HCP1) (Rajagopal et al

mice, rats, guinea pigs, hamsters) and strains (e.g