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It inhibits prostaglandin synthesis by modulating cyclooxygenase (COX) enzyme activityespecially COX-2 and a central COX-3 variantresulting in analgesic and antipyretic effects

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High levels of mtROS may hinder effective antigen presentation at stages subsequent to antigen uptake by directly causing oxidative damage to key proteins involved in pathways such as antigen processing, transport, or loading onto MHC molecules [161]

For severe or acute joint injuries, injectable forms are often preferred in research for their higher bioavailability