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Impaired activity of methionine synthase results in elevated blood concentrations of homocysteine, while impaired activity of L-methylmalonyl-CoA mutase results in increased concentrations of a metabolite of methylmalonyl-CoA called methylmalonic acid (MMA) in blood and urine

In certain breeds, B12 deficiency in dogs can be genetically passed on, especially in beagles, border collies, and giant schnauzers

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It is also known that oral contraceptives may lower pyridoxine levels in some individuals, which could be considered a drug-nutrient interaction of clinical relevance

The four main forms of B12: 1