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The oxidative pathway produced high tissue-reactive metabolites that lead to tissue injury and cell death

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Ma GY, Macaulay SL, Maggs JA, Armstrong JM, Bornstein J

BPC-157 upregulates VEGFR2 expression in vascular endothelial cells at both mRNA and protein levels without increasing VEGF-A production, suggesting the peptide sensitizes endothelial cells to existing VEGF rather than simply increasing ligand availability

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