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This is owing to the lack of understanding on the microbial pathophysiology

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Evidently, the gut microbiota affects ferroptosis by regulating iron metabolism and related metabolites, and ferroptosis plays a crucial role in the progression of CKD

[35] This has led to the recent proposal that the spectrum of autoimmunity should be viewed along an "immunological disease continuum", with classical autoimmune diseases at one extreme and diseases driven by the innate immune system at the other extreme