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Moreover, cells expressing the mutant M8-03-G were hypersensitive to verapamil + L-BSO, similarly to wild-type MRP1 and mutant M8-03 cells (Fig

Removal of breast cancer cells from extracellular matrix (ECM) and local invasion and migration initiation: Disruption of the connection of the cell to ECM through cellular adhesion proteins such as integrins, resulting in the dissociation of cancer cells from adjacent cells and the basement membrane, describes how metastasis begins (118)

For this population, the adverse effects of chelation therapy (hepatotoxicity, hypotension, coagulation disorders, etc.) outweigh the minimal therapeutic chelation efficiency observed with these chronic concentrations and is not recommended 27,28,29

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GHK-Cu has the stronger published research footprint because it is a specific peptide-copper complex

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