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[139] This could be associated with loss of blood during menstruation, or with pregnancy

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participation was 24 weeks [IQR 12-42]

Acknowledgements This work was supported by NIHR01HL160014 (to M.U.-F.), R01HL174014 (to T.F., M.U-F., V.S.), R01HL147550 (to T.F., M.U.-F.), P01HL160557 (to T.F., M.U-F), VA Merit Review grant I01BX001232 (to T.F.), AHA22TPA971863 (to T.F.)

Neurology 72:19141921 Griffiths I, Klugmann M, Anderson T, Yool D, Thomson C, Schwab MH, Schneider A, Zimmermann F, McCulloch M, Nadon N, Nave KA (1998) Axonal swellings and degeneration in mice lacking the major proteolipid of myelin

Although we performed multivariate adjust- ments, residual confounding may persist due to unmea- sured factors such as dietary habits (e.g., irregular intake of animal-derived foods or B12-fortied products), unrecorded use of nutritional supplements, and genetic predispositionsparticularly MTHFR polymorphisms, which are known to inuence homocysteine metabolism and folate cycling, thereby potentially altering the func- tional demand for vitamin B12