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A number of reports used HK-2 cells to study the kidney impairment in diabetes or after treatment with cisplatin, heavy metals or drugs (Garcia-Pastor et al

These perturbations synergistically attenuate cellular antioxidant capacity, promote iron retention, and amplify chronic retinal inflammation

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The activation of AMPK is linked to caloric restriction states where consumption of energy is reduced due to nutrition deprivation (Frank W Sellke, 2+ /calmodulin-dependent protein kinase kinase- (CaMKK)-dependent pathway (Shafique et al., 2013)