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Existing literature on ozone therapy reveals research gaps: limited comparative studies between treatments, unclear safety and effectiveness in various musculoskeletal conditions and insufficient understanding of anti-inflammatory effects [3, 18, 31]

The random-effect meta-analysis also derives the estimates by assigning weights to estimates from each replicate, but in this case the weights take into account the variation of estimates across replicates

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[0255] The embodiments, illustratively described herein may suitably be practiced in the absence of any element or elements, limitation or limitations, not specifically disclosed herein