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At later time points (T2-T4), a two-cluster solution was identified: resilient and symptomatic

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These advances have led to rapid succession to the approval of the anti-PD-1 antibodies pembrolizumab and nivolumab (both in 2014), followed by the anti-PD-L1 antibodies atezolizumab (in 2016) and durvalumab (in 2017), as second-line therapies for advanced melanoma and metastatic colorectal cancer (mCRC) [37]

When this happens, for example, fibers responsible for smiling may grow to the muscles at the corner of the mouth and eyelid thus causing lip movement and eye closure instead of a smile