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2.2 Mitochondrial dysfunction and oxidative stress Mitochondrial complex I deficiency is consistently observed in PD, leading to impaired ATP synthesis and overproduction of reactive oxygen species (ROS) (Chang and Chen, 2020

Vitamin B12 is water-soluble, and your kidneys excrete what you dont need

Hyaluronic Acid is a polysaccharide that occurs in high amounts in the skin, joints, and eyes, providing lubrication and keeping tissues hydrated

Typical non-nucleoside analogs include oligonucleotides, SAM competitors, natural compounds, and repurposed drugs with demethylating effects (Fig

The B12 component reduces nausea through the mechanism described earlier, but does not eliminate it at higher doses