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Both MT1 and MT2 receptors are highly susceptible to desensitization, their activity markedly decreases after exposure to supraphysiological concentrations of the hormone [23]

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doi: 10.1016/j.bbr.2008.11.051 193 RajkowskaG.Miguel-HidalgoJ

Cell Death Dis 16(1):312 Choi YK (2024) Detrimental roles of hypoxia-inducible factor-1 in severe hypoxic brain diseases