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Additional studies are required

In the Kmt2d +/Geo mouse model, treatment with KD for 2 weeks normalizes the global histone modification state corrects the neurogenesis deficiency in the granule cell layer of the dentate gyrus, and rescues the hippocampal memory defects (88)

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Patients with a positive baseline serum pgRNA had a worse prognosis and a higher cumulative recurrence rate after systemic treatment(Figure 1)