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Any researcher relying on the HGF/c-Met mechanistic model for Dihexa should independently review the current status of these publications, as the retractions materially weaken the direct biochemical evidence for the proposed mechanism, even though downstream behavioural (cognitive/spine-density) findings from the same research group have not themselves been retracted

lack of placebo controls for many studies, resulting in a likely over-estimation of efficacy

Genes detected in fewer than 10 cells were excluded from analysis