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The AR NTD is constitutively active in the absence of the LBD and thus can promote androgen depletion-resistant growth 138,153

As expected, the carbonyl function of a ketose may be reduced by sodium borohydride, usually to a mixture of epimeric products

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44 Thus, apart from tumor thickness greater than 5 mm and the presence of lymphovascular invasion, many of the histologic prognostic parameters of cutaneous melanoma (i.e., Breslows classification and Clarks level of invasion) do not apply to oral melanoma