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Moreover, the increased axonal regeneration and myelination observed in the treated groups was accompanied by enhanced levels of BDNF, an activation of Akt, and subsequently increased levels of p-mTORC1 and p-GSK3, which are all key players in axonal regeneration signaling cascades [62]

doi: 10.1126/scitranslmed.abq1533 60 GuoY.LuoR.WangY.DengP.SongT.ZhangM.et al

Mechanistically, p53 decreases the monoubiquitination rate of histone H2B on lysine 120 (H2Bub1) in the SLC7A11 gene regulatory region by facilitating the nuclear translocation of the deubiquitinase USP7, leading to the inactivation of SLC7A11 expression in erastin-treated cells [122]

Similarly, 16 male college long-distance runners who consented were randomized to placebo and CT groups and given the test food once a day at dinner for 7 days of regular training and 9 days during a training camp (daily for a total of 16 days)

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