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FEBS Lett

In numerous species, from nematodes to rodents, caloric restriction, which lowers IGF-I levels, has been associated with increased lifespan

It is often referred to as the "master antioxidant" due to its crucial role in neutralizing harmful free radicals within the body

With training, higher levels can mean stronger gains and faster recovery

Downstream pathway activity profiling involving endocrine modulation

What the mechanism does NOT prove: Demonstrating a GH pulse in a pharmacokinetic study does not establish that this translates into clinically meaningful body composition change, injury recovery, or anti-aging benefit in healthy adults over months or years