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The case of NAC encapsulates the core challenges of MIRI therapy: while its mechanism of enhancing endogenous defenses is conceptually superior to direct scavenging (as argued in Section 2.3), its clinical potential is ultimately nullified by the formidable practical hurdles of delivery and timing required to counteract the rapid and localized oxidative burst (Section 2.1)

All studies were performed with the approval of the University of Kentucky Institutional Animal Care and Use Committee

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By increasing cGMP levels, this compound favors the transport of nutrients, improves endurance and helps reduce muscle fatigue