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It was clinically approved by both the Food and Drug Administration (FDA) and the European Medicine Agency (EMA) in 2014 for the treatment of relapsing-remitting multiple sclerosis (MS), showing a significant efficacy over 2 years versus placebo and a favorable benefit-risk profile in two phase-III clinical trials, although with several adverse effects such as nausea, diarrhea, abdominal pain and leukopenia in some patients [282, 283]

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65) and KG1a 66 leukemia cell lines were obtained from the German Collection of Microorganisms and Cell Cultures (DSMZ)

Per sample, 36 cardiac MTs or 54 hepatic MTs were used in order to obtain sufficient amounts of RNA for sequencing