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Yuneva MO, Fan TWM, Allen TD, Higashi RM, Ferraris DV, Tsukamoto T, et al

British Journal of Haematology 1998;101(3) 399-406 18

S.TaylorP.ShawL

Inhibiting pathways associated with ammonia-induced cell death can enhance CD8+ T-cell survival, significantly improving the effectiveness of adoptive cell therapy ( Current targeting strategies continue to confront a triple paradox: First, while inhibition of glutamine metabolism enhances memory differentiation of T cells (60), it may exacerbate nutrient competition within the tumor microenvironment

Advances in treatment over the last 20 years has led to the development of antibody and small molecule medications which are very effective and with fewer side-effect or contra-indications to taking