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The calculation for pI involves averaging the pKa values associated with the carboxyl and the third ionizable group, resulting in a pI of 2.77, expressed as: pI = 1/2 (pKa1 + pKa3)

doi: 10.1002/jcp.20282 50 LinesKENeweyPJYatesCJStevensonMDyarRWallsGVet al

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Last updated: May 15, 2012 Scientists Identify New Leads for Treating Parasitic Worm Disease National Human Genome Research Institute (NHGRI) www.genome.gov National Institute of Allergy and Infections Diseases (NIAID) www.niaid.nih.gov Scientists Identify New Leads for Treating Parasitic Worm Disease Compounds May Provide Much-Needed New Weapons in Worldwide Battle Against Schistosomiasis Bethesda, Md

However, we did not find clinical studies with other metal-based compounds, which restricted the discussion on the topic