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Male fertility is highly influenced by environmental, lifestyle and medical factors, with evidence showing that both short-term and long-term interventions such as nutritional supplementation and lifestyle changes can lead to substantial improvements in semen quality and fertility potential

Increases in plasma homocysteine concentration is strongly associated with cardiovascular disease, and supplementation of folic acid can lower plasma homocysteine levels (Kaye et al., 2020)

These conditions share common mechanisms involving disrupted redox homeostasis, elevated oxidative stress, and impaired detoxification, underscoring the therapeutic potential of strategies aimed at restoring glutathione balance to mitigate disease progression