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Average library size and concentration were determined using TapeStation and qPCR (NEBNext Library Quant kit, New England Biolabs), respectively, before pooling

Moreover, several findings demonstrate that mutations in oncogenes and /or tumor suppressor genes can mediate metabolic rewiring in cancer cells to support the high demands for building blocks and energy production (63)

A reduction in intracellular lactate levels, primarily due to excessive efflux and consumption by cardiomyocytes, contributes significantly to diminished lactylation at the K1897 site of -myosin heavy chain during myocardial injury [62]

Endocrinol Metab 38(5):482492

doi: 10.1016/j.chom.2012.06.006 102 SaeedSQuintinJKerstensHHRaoNAAghajanirefahAMatareseFet al

Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors