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Based on the available data we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome

The metabolic syndrome and risk of major coronary events in the Scandinavian Simvastatin Survival Study (4S) and the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS)

Additionally, because low NAD+ is linked to aging, its decline could contribute to the development of various age-related health concerns, including cardiovascular disease, metabolic disorders, the development of neurodegenerative diseases such as Alzheimers and Parkinsons, and cancer