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A randomized, double-blind, placebo-controlled trial in 60 Thai medical students found that glutathione (500 mg/day for 4 weeks) reduced melanin index scores at multiple body sites compared to placebo (Arjinpathana & Asawanonda, J Dermatolog Treat, 2012) [61]

doi: 10.1016/j.bbrc.2004.09.220

Glutathione IV therapy is available at The Center for Occupational and Environmental Medicine (COEM)

Another example of polyphenols is resveratrol, which has been reported to have various biological properties such as immunomodulation, antioxidation, hepatoprotection, anti-inflammation, regulation of lipid metabolism, and others (158160)

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Studies in aged humans and rodents have shown that dietary supplementation with the precursors of glutathione, CYS and/or GLY, can restore glutathione synthesis and reduce levels of oxidative stress