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The process of lewy body formation, rather than simply alpha-synuclein fibrillization, is one of the major drivers of neurodegeneration

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The status and body weights of mice were monitored

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Mechanistic Studies Subsequent research has explored the mechanisms by which NNMT regulates metabolism, with studies demonstrating that NNMT activity reduces cellular NAD+ availability, affects SAM-dependent methylation reactions, modulates sirtuin activity, and influences adipocyte differentiation and function